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Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.

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Authors and Affiliations

  1. Central Research Laboratory, M. Gorky Donetsk National Medical University, Donetsk, Ukraine

    M. A. Stashkevich, E. V. Khomutov, Yu. V. Dumanskii, A. G. Matvienko & I. I. Zinkovich

Authors
  1. M. A. Stashkevich
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  2. E. V. Khomutov
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  3. Yu. V. Dumanskii
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  4. A. G. Matvienko
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  5. I. I. Zinkovich
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Corresponding author

Correspondence to A. G. Matvienko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 11, pp. 593-595, November, 2015

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Stashkevich, M.A., Khomutov, E.V., Dumanskii, Y.V. et al. Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment. Bull Exp Biol Med 160, 646–648 (2016). https://doi.org/10.1007/s10517-016-3239-z

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  • DOI: https://doi.org/10.1007/s10517-016-3239-z

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