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Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated. Administration of deferoxamine in a dose of 1 g/kg induced hypoplasia of the erythroid hemopoietic lineage. Suppression of bone marrow erythropoiesis manifested in a decrease of hemoglobin concentration and counts of reticulocytes, erythrocytes, and erythrokaryocytes. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. These data indicate that deferoxamine can be used for modeling of iron defi ciency anemia in pregnancy.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

    V. V. Zhdanov, E. V. Udut, L. S. Sotnikova, Ya. V. Burmina, L. A. Miroshnichenko, E. V. Simanina, T. Yu. Polyakova, G. N. Zyuz’kov, A. V. Chaikovskii, L. A. Stavrova, E. P. Fedorova & A. M. Dygai

Authors
  1. V. V. Zhdanov
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  2. E. V. Udut
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  3. L. S. Sotnikova
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  4. Ya. V. Burmina
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  5. L. A. Miroshnichenko
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  6. E. V. Simanina
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  7. T. Yu. Polyakova
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  8. G. N. Zyuz’kov
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  9. A. V. Chaikovskii
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  10. L. A. Stavrova
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  11. E. P. Fedorova
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  12. A. M. Dygai
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Corresponding author

Correspondence to E. V. Udut.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 412-415, October, 2015

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Zhdanov, V.V., Udut, E.V., Sotnikova, L.S. et al. Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period. Bull Exp Biol Med 160, 417–420 (2016). https://doi.org/10.1007/s10517-016-3185-9

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  • DOI: https://doi.org/10.1007/s10517-016-3185-9

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