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Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia

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Bulletin of Experimental Biology and Medicine Aims and scope

Here we studied the cytoprotective effect of lithium chloride and sodium valproate in the in vivo model of neonatal cerebral ischemia/hypoxia and analyzed the influence of these substances on the death of the major neurovascular unit components in experimental ischemia in vitro. Lithium chloride and sodium valproate effectively prevented death of neurons, astrocytes, and endothelial cells in the oxygen-glucose deprivation. This treatment protected the brain of newborn rats from ischemia/hypoxia injury. The results suggest that lithium and sodium valproate can be used for the treatment of neurodegenerative pathologies associated with hypoxia and ischemia in newborns.

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References

  1. D. N. Silachev, A. A. Uchevatkin, Yu. A. Pirogov, et al., Bull. Exp. Biol. Med., 147, No. 2, 269-272 (2009).

    Article  PubMed  CAS  Google Scholar 

  2. D. N. Silachev, M. I. Shubina, S. S. Yanauskas, et al., Zh. Vyssh. Nervn. Deyat., 63, No. 3, 405 (2013).

    CAS  Google Scholar 

  3. G. J. Brewer, J. Neurosci. Res., 42, No. 5, 674-683 (1995).

    Article  PubMed  CAS  Google Scholar 

  4. G. Buonocore and F. Groenendaal, Semin. Fetal Neonatal Med., 12, No. 4, 287-295 (2007).

    Article  PubMed  Google Scholar 

  5. G. J. del Zoppo, J. Intern. Med., 267, No. 2, 156-171 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  6. U. Förstermann, Pflugers Arch., 459, No. 6, 923-939 (2010).

    Article  PubMed  Google Scholar 

  7. A. Gelot, S. Villapol, T. Billette de Villemeur, et al., Dev. Neurosci., 31, No. 5, 459-470 (2009).

    Article  PubMed  CAS  Google Scholar 

  8. Y. Gursoy-Ozdemir, M. Yemisci, and T. Dalkara, J. Neurochem., 123, Suppl. 2, 2-11 (2012).

    Article  PubMed  CAS  Google Scholar 

  9. K. D. McCarthy and J. de Vellis, J. Cell Biochem., 85, No. 3, 890-902 (1980).

    CAS  Google Scholar 

  10. M. A. Moskowitz, E.H. Lo, and C. Iadecola, Neuron, 67, No. 2, 181-198 (2010).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. D. N. Silachev, L. S. Khailova, V. A. Babenko, et al., Biochim. Biophys. Acta, 1840, No. 12, 3434-3442 (2014).

    Article  PubMed  CAS  Google Scholar 

  12. E. J. Sohn, D.W. Kim, M. J. Kim, et al., Biochim. Biophys. Acta, 1820, No. 10, 1647-1655 (2012).

    Article  PubMed  CAS  Google Scholar 

  13. L. P. Sutton and W. J. Rushlow, Neuroscience, 199, 116-124 (2011).

    Article  PubMed  CAS  Google Scholar 

  14. Z. F. Wang, E.B. Fessler, and D. M. Chuang, Acta Pharmacol. Sin., 32, No. 12, 1433-1445 (2011).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  15. A. Witthoft and G. Em Karniadakis, J. Theor. Biol., 311, 80-93 (2012).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. A. N. Belozersky Institute of Physical and Chemical Biology, Moscow, Russia

    D. N. Silachev, E. Yu. Plotnikov, I. B. Pevzner & D. B. Zorov

  2. Faculty of Bioengineering and Bioinformatics, Moscow, Russia

    V. A. Babenko & E. S. Savchenko

  3. International Laser Research Centre, M. V. Lomonosov Moscow State University, Moscow, Russia

    L. D. Zorova

  4. V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    V. A. Babenko & G. T. Sukhikh

  5. Faculty of Physics, M. V. Lomonosov Moscow State University, Moscow, Russia

    M. V. Gulyaev & Yu. A. Pirogov

Authors
  1. D. N. Silachev
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  2. E. Yu. Plotnikov
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  3. V. A. Babenko
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  4. E. S. Savchenko
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  5. L. D. Zorova
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  6. I. B. Pevzner
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  7. M. V. Gulyaev
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  8. Yu. A. Pirogov
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  9. G. T. Sukhikh
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  10. D. B. Zorov
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Corresponding author

Correspondence to D. B. Zorov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 9, pp. 295-301, September, 2015

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Silachev, D.N., Plotnikov, E.Y., Babenko, V.A. et al. Protection of Neurovascular Unit Cells with Lithium Chloride and Sodium Valproate Prevents Brain Damage in Neonatal Ischemia/Hypoxia. Bull Exp Biol Med 160, 313–318 (2016). https://doi.org/10.1007/s10517-016-3159-y

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  • DOI: https://doi.org/10.1007/s10517-016-3159-y

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