Skip to main content
SpringerLink
Log in

Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The mechanism of disruptive action of dichlorodiphenyltrichloroethane (DDT) on the function of thyroid follicular epitheliocytes was examined in mature male Wistar rats administered with a daily dose of DDT (2 μg/kg) for 6 or 10 weeks. In 6 weeks, the serum level of Na+/I– symporter responsible for the transport of iodides into follicular thyrocytes decreased, while serum concentration of thyroperoxidase increased. In 10 weeks, both the number of follicles in the thyroid gland and serum level of Na+/I– symporter increased. In circulating blood, the concentrations of thyroglobulin as well as α and β receptors of the thyroid hormones did not change. DDT down-regulated the iodine-accumulated function of follicular thyrocytes by suppressing Na+/I– symporter synthesis. Recovery of Na+/I– symporter production resulted from up-regulation of the proliferative processes in thyroid gland.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. SanPin 2.3.2.1078-01. Directives on Hygienic Safety and Nutritional Value of Foodstuffs [in Russian], (2001).

  2. N. V. Yaglova and V. V. Yaglov, Bull. Exp. Biol. Med., 156, No. 6, 760-762 (2014).

    Article  CAS  PubMed  Google Scholar 

  3. A. Cheek, K. Kow, Y. Chen, and J. McLachlan, Environ. Health Perspect., 107, No. 4, 273-278 (1999).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. B. De Groef, B. Decallonne, S. Van der Geyten, et al., Eur. J. Endocrinol., 155, No. 1, 17-25 (2006).

    Article  PubMed  Google Scholar 

  5. C. Liu, Y. Shi, H. Li, et al., Horm. Metab. Res., 43, No. 6, 391-396 (2011).

    Article  CAS  PubMed  Google Scholar 

  6. T. Schug, A. Janesick, B. Blumberg, and J. J. Heindel, J. Steroid Biochem. Mol. Biol., 127, Nos. 3-5, 204-215 (2011).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. State of the Science of Endocrine Disrupting Chemicals – 2012, Eds. Å. Bergman, et al., Geneva (2013).

  8. O. Tebourbi, D. Hallegue, M. T. Yacoubi, et al., Environ. Toxicol. Pharmacol., 29, No. 3, 271-279 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. The 2013 Berlaymont Declaration on Endocrine Disruptors. http://www.brunel.ac.uk/data/assets/pdf_fi le/0005/300200/The_Berlaymont_Declaration_on_Endocrine_Disrupters.pdf

  10. The Impacts of Endocrine Disrupters on Wildlife, People, and Their Environments. The Weybridge+15 (1996-2011) Report, Eur. Envir. Agency Tech. Report, No. 2, Copenhagen (2012).

Download references

Author information

Authors and Affiliations

  1. Research Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia

    N. V. Yaglova & V. V. Yaglov

Authors
  1. N. V. Yaglova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. V. Yaglov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. V. Yaglova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 8, pp. 196-199, August, 2015

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yaglova, N.V., Yaglov, V.V. Mechanisms of Disruptive Action of Dichlorodiphenyltrichloroethane (DDT) on the Function of Thyroid Follicular Epitheliocytes. Bull Exp Biol Med 160, 231–233 (2015). https://doi.org/10.1007/s10517-015-3136-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-015-3136-x

Key Words

Search

Navigation