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Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic

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Bulletin of Experimental Biology and Medicine Aims and scope

Injection of a glucagon-like peptide-1 mimetic accelerated recovery of the initial status of water-salt balance in rats after water or saline load (2.5% NaCl). This effect is mediated by a decrease in proximal fluid reabsorption and change in ion and water transport in the distal part of renal tubules. We developed a new approach to calculation of additional fluid inflow from the proximal tubule to the distal tubule and distal sodium reabsorption under the influence of this mimetic in rats. The expected values corresponded to experimental results, which confirmed our hypothesis on the physiological mechanism for the involvement of the kidneys in the homeostatic effect of glucagon-like peptide-1 under variations in water-salt balance.

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Authors and Affiliations

  1. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    Yu. V. Natochin, A. S. Marina & A. V. Kutina

Authors
  1. Yu. V. Natochin
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  2. A. S. Marina
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  3. A. V. Kutina
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Correspondence to Yu. V. Natochin.

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Natochin, Y.V., Marina, A.S. & Kutina, A.V. Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic. Bull Exp Biol Med 160, 9–12 (2015). https://doi.org/10.1007/s10517-015-3085-4

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  • DOI: https://doi.org/10.1007/s10517-015-3085-4

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