RHAMM-selective peptides in a concentration of 10 μg/ml (2×10–7 M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h. Treatment of cancer cells with RHAMM-selective peptides induced apoptosis and necrosis and increased caspase-3 activity (by 30%).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 618-621, May, 2015
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Akent’eva, N.P., Shushanov, S.S. & Kotel’nikov, A.I. Effects of RHAMM/HMMR-Selective Peptides on Survival of Breast Cancer Cells. Bull Exp Biol Med 159, 658–661 (2015). https://doi.org/10.1007/s10517-015-3041-3
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DOI: https://doi.org/10.1007/s10517-015-3041-3