The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 5, pp. 601-604, May, 2015
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Zyuz’kov, G.N., Zhdanov, V.V., Udut, E.V. et al. Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine. Bull Exp Biol Med 159, 642–645 (2015). https://doi.org/10.1007/s10517-015-3036-0
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DOI: https://doi.org/10.1007/s10517-015-3036-0