We studied the role of cAMP- and IKK-2-dependent pathways under conditions of functional stimulation of mesenchymal progenitor cells by basic fibroblast growth factor. An adenylate cyclase inhibitor 2’,5’-dideoxyadenosine had no effect on functional activity of early (primitive) mesenchymal precursors. This agent produced a stimulatory effect on proliferation of stromal precursor cells. Mitotic activity of mesenchymal progenitor cells was shown to decrease after treatment with a specific blocker of the IKK-2 kinase-inhibitor complex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Manual on Preclinical Studies of New Medicinal Agents [in Russian], Ed. A. N. Mironov, Moscow (2013), pp. 778-789.
G. N. Zyuz’kov, V. V. Zhdanov, M. G. Danilets, et al., Bull. Exp. Biol. Med., 156, No. 2, 228-231 (2013).
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Bull. Exp. Biol. Med., 148, No. 1, 120-125 (2009).
A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Stem Cell Rev., 9, No. 2, 140-147 (2013).
O. I. Epstein, G. N. Zyuz’kov, N. V. Sotnikova, et al., Bull. Exp. Biol. Med., 140, No. 5, 598-602 (2005).
E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, et al., Bull. Exp. Biol. Med., 143, No. 4, 548-551 (2007).
E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, and V. V. Zhdanov, Bull. Exp. Biol. Med., 144, No. 6, 802-805 (2007).
L. Lou, J. Urbani, F. Ribeiro-Neto, and D. L. Altschuler, J. Biol. Chem., 277, No. 36, 32,799-32,806 (2002).
M. Mohammadi, S. K. Olsen, and O. A. Ibrahimi, Cytokine Growth Factor Rev., 16, No. 2, 107-137 (2005).
G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, et al., Bull. Exp. Biol. Med., 155, No. 6, 721-725 (2013).
G. N. Zyuz’kov, L. A. Gur’yantseva, E. V. Simanina, et al., Bull. Exp. Biol. Med., 143, No. 4, 535-538 (2007).
G. N. Zyuz’kov, L. A. Gur’yantseva, N. I. Suslov, et al., Bull. Exp. Biol. Med., 134, No. 4, 325-328 (2002).
G. N. Zyuz’kov, A. V. Krapivin, Yu. V. Nesterova, et al., Bull. Exp. Biol. Med., 153, No. 6, 847-851 (2012).
G. N. Zyuz’kov, N. I. Suslov, A. M. Dygai, et al., Bull. Exp. Biol. Med., 140, No. 5, 606-611 (2005).
G. N. Zyuz’kov, V. V. Zhdanov, A. M. Dygai, and E. D. Gol’dberg, Bull. Exp. Biol. Med., 144, No. 6, 840-845 (2007).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 186-189, February, 2014
Rights and permissions
About this article
Cite this article
Zyuz’kov, G.N., Zhdanov, V.V., Danilets, M.G. et al. Involvement of cAMP- and IKK-2-Dependent Signal Pathways in the Growth Capacity of Mesenchymal Progenitor Cells under the Influence of Basic Fibroblast Growth Factor. Bull Exp Biol Med 157, 224–227 (2014). https://doi.org/10.1007/s10517-014-2530-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2530-0