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Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade

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Bulletin of Experimental Biology and Medicine Aims and scope

Glufimet (glutamic acid derivative) in a dose of 28.7 mg/kg limited the reduction of the cardiac functional reserve in animals subjected to 24-h stress under conditions of nonselective NO synthase blockade with L-NAME (10 mg/kg). Adrenoreactivity and increased afterload tests showed that the increment of myocardial contraction/relaxation rates, left-ventricular pressure, and HR were significantly higher in glufimet-treated stressed animals with NO synthesis blockade than in animals which received no glufimet. The efficiency of glufimet was higher than that of phenibut (the reference drug).

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Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    I. N. Tyurenkov, V. N. Perfilova, N. V. Sadikova, V. M. Berestovitskaya & O. S. Vasil’eva

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  1. I. N. Tyurenkov
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  2. V. N. Perfilova
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  3. N. V. Sadikova
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  4. V. M. Berestovitskaya
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  5. O. S. Vasil’eva
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Correspondence to V. N. Perfilova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 366–368, March, 2015

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Tyurenkov, I.N., Perfilova, V.N., Sadikova, N.V. et al. Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade. Bull Exp Biol Med 159, 384–386 (2015). https://doi.org/10.1007/s10517-015-2969-7

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  • DOI: https://doi.org/10.1007/s10517-015-2969-7

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