We studied possible mechanisms of immunosuppression mediated by regulatory T cells that promotes suppression of antigen-specific immune response to Mycobacterium tuberculosis in patients with pulmonary tuberculosis and eosinophilia. It was shown that the number of CD4+CD25+Foxp3+ regulatory T cells with immunosuppressive activity (Treg) increased in the peripheral blood of patients with disseminated destructive forms of pulmonary tuberculosis with multiple resistance of the causative agent to antituberculosis substances and eosinophilia. These changes were accompanied by imbalance in secretion of Treg-associated cytokines (in vitro) manifested in hyperproduction of TGFβ and IL-10 and decreased production of IL-2.
Similar content being viewed by others
References
V. V. Novitskii, E. G. Churina, O. I. Urazova, et al., Immunologiya, 33, No. 4, 184-188 (2012).
E. G. Churina, O. I. Urazova, V. V. Novitskii, et al., Klin. Lab. Diagnost., No. 4, 26-29 (2012).
E. G. Churina, O. I. Urazova, V. V. Novitskiy, Tuberc. Res. Treat., 2012, 931291 (2012).
T. R. Malek, and A. L. Bayer, Nat. Rev. Immunol., 4, No. 9, 665-674 (2004).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 300-304, March, 2015
Rights and permissions
About this article
Cite this article
Urazova, O.I., Novitskii, V.V., Kolobovnikova, Y.V. et al. Factors of Suppression of Immune Response in Patients with Pulmonary Tuberculosis and Eosinophilia. Bull Exp Biol Med 159, 323–326 (2015). https://doi.org/10.1007/s10517-015-2952-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2952-3