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Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis

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The parameters characterizing antituberculous immune response at the stage of cytokinedependent activation of T cells were analyzed in 90 patients with pulmonary tuberculosis before etiotropic therapy. Immunophenotyping of T cells for IL-12Rβ2, WSX-1, and gp130 surface markers and T-bet intracellular transcription factor was carried out after specific IL-12/IL-27 induction of cells in vitro. An increase in the counts of CD3+T-bet+, CD3+IL-12Rβ2 +, and CD3+WSX-1+gp130+ cells and the level of T cells with high expression of WSX-1 inhibitory molecule (CD3+WSX-1hi+gp130− and CD3+WSX-1hi+gp130+) was detected. The type of disorders in the inductive stage of antituberculous immune response did not depend on the clinical form of disease.

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Authors and Affiliations

  1. Siberian State Medical University, Tomsk, Russia

    I. E. Esimova, O. I. Urazova, M. S. Ignatova, V. V. Novitskii & Yu. V. Kolobovnikova

  2. National Research Tomsk State University, Tomsk, Russia

    V. V. Novitskii

Authors
  1. I. E. Esimova
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  2. O. I. Urazova
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  3. M. S. Ignatova
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  4. V. V. Novitskii
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  5. Yu. V. Kolobovnikova
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Correspondence to I. E. Esimova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 373–376, March, 2015

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Esimova, I.E., Urazova, O.I., Ignatova, M.S. et al. Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis. Bull Exp Biol Med 159, 390–392 (2015). https://doi.org/10.1007/s10517-015-2971-0

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  • DOI: https://doi.org/10.1007/s10517-015-2971-0

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