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Effect of Sodium Nitrite and L-NNA on the Outcome of Experimental Ischemic Stroke

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of sodium nitrite in doses of 5 and 50 mg/kg and NO synthase inhibitor L-NNA in a dose of 20 mg/kg on the course of experimental ischemic stroke caused by occlusion of both carotid arteries. Sodium nitrite and NO synthase inhibitor were administered 1 h prior to occlusion of еру carotid arteries and 5 sec after brain ischemia. Sodium nitrite in a dose of 5 mg/kg had a protective effect on the time course of neurological disorders and reduced animal mortality. NO synthase inhibitor L-NNA aggravated the neurological symptoms.

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Authors and Affiliations

  1. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    V. S. Kuzenkov & A. L. Krushinskii

Authors
  1. V. S. Kuzenkov
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  2. A. L. Krushinskii
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Correspondence to V. S. Kuzenkov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 2, pp. 174-177, February, 2015

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Kuzenkov, V.S., Krushinskii, A.L. Effect of Sodium Nitrite and L-NNA on the Outcome of Experimental Ischemic Stroke. Bull Exp Biol Med 159, 217–220 (2015). https://doi.org/10.1007/s10517-015-2926-5

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  • DOI: https://doi.org/10.1007/s10517-015-2926-5

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