We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following pharmacokinetic parameters were calculated: maximum plasma concentration of dilept, time to maximum observed concentration, area under the pharmacokinetic curve, elimination half-life, and relative bioavailability. Dilept concentration in blood plasma was estimated using ultra-fast liquid chromatography with mass spectrometry detection. Relative bioavailability of dilept tablets was 93.46±28.91% of that for the substance.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 704-706, June, 2014
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Shevchenko, R.V., Litvin, A.A., Kolyvanov, G.B. et al. Comparison of Pharmacokinetics and Relative Bioavailability of Tablets and Substance of New Dipeptide Neuroleptic Dilept. Bull Exp Biol Med 157, 735–737 (2014). https://doi.org/10.1007/s10517-014-2655-1
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DOI: https://doi.org/10.1007/s10517-014-2655-1