Serum levels of sRANKL, RANK, OPG, IL-8, IL-6, IL-16, MMP-2, and calcitonin were measured by ELISA in patients with malignant, borderline, and benign bone tumors and in healthy individuals (control). Serum levels of RANK, OPG, IL-8, IL-6, and the OPG/sRANKL ratio were signifi cantly higher, while the level of MMP-2 was signifi cantly lower in patients with bone tumors than in controls. Serum concentration of IL-16 in osteosarcoma patients was signifi cantly lower than in chondrosarcoma patients. No signifi cant differences between bone sarcomas of different differentiation were detected for any of the studied markers. Calcitonin level depended on the tumor location and type.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. S. Gerstein, E. A. Korotkova, V. V. Prorokov, and N. E. Kushlinsky, Bull. Exp. Biol. Med., 145, No. 3, 362-366 (2008).
E. S. Gerstein, N. V. Levkina, M. A. Digayeva, et al., Bull. Exp. Biol. Med., 149, No. 5, 628-631 (2010).
N. E. Kushlinsky, Yu. N. Solovyov, I. V. Babkina, et al., Bull. Exp. Biol. Med., 149, No. 2, 233-235 (2010).
ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed., Washington D. C. (2008), P. 537.
J. Costa-Rodriguez, C. A. Teixeira, and M. H. Fernandes, Clin. Exp. Metastasis, 28, No. 6, 505-514 (2011).
W. C. Dougall, Clin. Cancer Res., 18, No. 5, 326-335 (2012).
D. Hanahan and R. A. Weinberg, Cell, 144, No. 5, 646-674 (2011).
C. J. Hsu, T. Y. Lin, C. C. Kuo, et al., J. Cell. Biochem., 111, No. 1, 138-147 (2010).
H. L. Jorgensen, P. Kusk, B. Madsen, et al., J. Bone Miner. Metab., 22, No. 2, 132-138 (2004).
J. A. Lee, J. S. Jung, D. H. Kim, et al., Pediatr. Blood Cancer, 56, No. 5, 738-743 (2011).
B. Liu, S. F. Yu, and T. J. Li, J. Oral Pathol. Med., 32, No. 6, 367-375 (2003).
G. R. Mundy, Nat. Rev. Cancer, 2, No. 8, 584-593 (2002).
P. Rutkowski, J. Kamińska, M. Kowalska, et al., J. Surg. Oncol., 84, No. 3, 151-159 (2003).
E. Terpos, R. Szydlo, J. F. Apperley, et al., Blood, 102, No. 3, 1064-1069 (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 522-526, April, 2014
Rights and permissions
About this article
Cite this article
Kushlinskii, N.E., Timofeev, Y.S., Solov’ev, Y.N. et al. Components of the RANK/RANKL/OPG System, IL-6, IL-8, IL-16, MMP-2, and Calcitonin in the Sera of Patients with Bone Tumors. Bull Exp Biol Med 157, 520–523 (2014). https://doi.org/10.1007/s10517-014-2605-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2605-y