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Effects of Interleukin-18 on Bioelectric Activity of Rat Atrial Cardiomyocytes under Normal Conditions and during Gradual Stretching of the Tissue

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Effects of IL-18 (50 ng/ml) on bioelectric activity of rat atrial cardiomyocytes under normal conditions and after gradual stretching of the tissue was studied using microelectrode technique. It was shown that in 85% experiments, IL-18 increased the duration of action potential at the level of 25, 50, and 90% repolarization without changing the magnitude of the resting potential, amplitude and repetition rate of action potentials, and cardiomyocyte contraction force. In addition, IL-18 abolished mechanically induced changes in the shape of action potentials during stretching.

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Authors and Affiliations

  1. Department of Physiology, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    V. M. Mitrokhin, E. Yu. Makarenko, D. V. Abramochkin, P. V. Sutyagin & A. G. Kamkin

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  1. V. M. Mitrokhin
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  2. E. Yu. Makarenko
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  3. D. V. Abramochkin
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  4. P. V. Sutyagin
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  5. A. G. Kamkin
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Corresponding author

Correspondence to E. Yu. Makarenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 401-404, April, 2014

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Mitrokhin, V.M., Makarenko, E.Y., Abramochkin, D.V. et al. Effects of Interleukin-18 on Bioelectric Activity of Rat Atrial Cardiomyocytes under Normal Conditions and during Gradual Stretching of the Tissue. Bull Exp Biol Med 157, 409–412 (2014). https://doi.org/10.1007/s10517-014-2578-x

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  • DOI: https://doi.org/10.1007/s10517-014-2578-x

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