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Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of neuropeptide Y in concentrations of 10—8-10—6 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10—7 and 10—6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10—6 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10—8 M it produced no significant changes.

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References

  1. Ziiatdinova NI, Zefirov AL, Sitdikov FG, Zefirov TL. Autonomic control of cardiac function involves modulation of hyperpolarization activated channels in vitro. Ross. Fiziol. Zh. 2003;89(2):154-160. Russian.

    CAS  Google Scholar 

  2. Masliukov PM, Yemanuilov AI, Bulibin AV, Zverev AA, Anikina TA. Morphological peculiarities of neuropeptide Y-ergic innervation of the heart in postnatal ontogenesis. Morfologiya. 2014;146(6):46-50. Russian.

    Google Scholar 

  3. Resnik AV, Fedorov VV, Rosenshtraukh LV. Ionic channels and currents in the cardiomyocytes. Kardiologiya. 2006;46(2):4-18. Russian.

    Google Scholar 

  4. Callanan EY, Lee EW, Tilan JU, Winaver J, Haramati A, Mulroney SE, Zukowska Z. Renal and cardiac neuropeptide Y and NPY receptors in a rat model of congestive heart failure. Am. J. Physiol. Renal Physiol. 2007;293(6):F1811-F1817.

    Article  CAS  Google Scholar 

  5. Dobreka Ł, Skowrona B, Baranowskaa A, Malska-Woźniakb A, Ciesielczyka K, Thorac PJ. Spectral heart rate variability and selected biochemical markers for autonomic activity in rats under pentobarbital anesthesia. Pol. Ann. Med. 2017; 24(2):180-187.

    Article  Google Scholar 

  6. Haass M, Cheng B, Richardt G, Lang RE, Schömig A. Characterization and presynaptic modulation of stimulation-evoked exocytotic co-release of noradrenaline and neuropeptide Y in guinea pig heart. Naunyn Schmiedebergs Arch. Pharmacol. 1989;339(1-2):71-78.

    Article  CAS  Google Scholar 

  7. Masliukov PM, Konovalov VV, Emanuilov AI, Nozdrachev AD. Development of neuropeptide Y-containing neurons in sympathetic ganglia of rats. Neuropeptides. 2012;46(6):345-352.

    Article  CAS  Google Scholar 

  8. Masliukov PM, Moiseev K, Emanuilov AI, Anikina TA, Zverev AA, Nozdrachev AD. Development of neuropeptide Y-mediated heart innervation in rats. Neuropeptides. 2016;55:47-54.

    Article  CAS  Google Scholar 

  9. McDermott BJ, Bell D. NPY and cardiac diseases. Curr. Top. Med. Chem. 2007;7(17):1692-1703.

    Article  CAS  Google Scholar 

  10. Onuoha GN, Nicholls DP, Alpar EK, Ritchie A, Shaw C, Buchanan K. Regulatory peptides in the heart and major vessels of man and mammals. Neuropeptides. 1999;33(2):165-172.

    Article  CAS  Google Scholar 

  11. Protas L, Qu J, Robinson R.B. Neuropeptide y: neurotransmitter or trophic factor in the heart. News Physiol. Sci. 2003; 18:181-185.

    CAS  PubMed  Google Scholar 

  12. Richardson RJ, Grkovic I, Anderson CR. Immunohistochemical analysis of intracardiac ganglia of the rat heart. Cell. Tissue Res. 2003;314(3):337-350.

    Article  CAS  Google Scholar 

  13. Zverev AA, Anikina TA, Maslyukov PM, Zefirov TL. Role of neuropeptide Y in myocardial contractility of rats during early postnatal ontogeny. Bull. Exp. Biol. Med. 2014;157(4):421-423.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    A. A. Zverev, T. A. Anikina, N. G. Iskakov & T. L. Zefirov

  2. Department of Normal Physiology, Kazan State Medical University of Ministry of Health of Russia, Kazan, Tatarstan Republic, Russia

    A. L. Zefirov

Authors
  1. A. A. Zverev
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  2. T. A. Anikina
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  3. N. G. Iskakov
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  4. A. L. Zefirov
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  5. T. L. Zefirov
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Correspondence to A. A. Zverev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 550-552, May, 2018

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Zverev, A.A., Anikina, T.A., Iskakov, N.G. et al. Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart. Bull Exp Biol Med 165, 610–612 (2018). https://doi.org/10.1007/s10517-018-4224-5

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  • DOI: https://doi.org/10.1007/s10517-018-4224-5

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