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Role of NF-κB-Dependent Signaling in the Growth Capacity of Mesenchymal Progenitor Cells Under the Influence of Basic Fibroblast Growth Factor

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the in vitro role of NF-κB-dependent signaling in the growth capacity of mesenchymal progenitor cells upon stimulation by basic fi broblast growth factor. Proliferative activity of progenitor cells was suppressed by specifi c inhibitors of this transcription factor (NF-κB), oridonin and aurothiomalate. These inhibitors had no effect on differentiation of fi broblast CFU.

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Authors and Affiliations

  1. Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, A. V. Chaikovskii, E. V. Simanina, E. S. Trofi mova, M. Yu. Minakova, E. A. Losev, V. V. Udut & A. M. Dygai

Authors
  1. G. N. Zyuz’kov
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  2. M. G. Danilets
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  3. A. A. Ligacheva
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  4. V. V. Zhdanov
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  5. E. V. Udut
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  6. L. A. Miroshnichenko
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  7. A. V. Chaikovskii
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  8. E. V. Simanina
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  9. E. S. Trofi mova
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  10. M. Yu. Minakova
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  11. E. A. Losev
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  12. V. V. Udut
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  13. A. M. Dygai
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 331-334, March, 2014

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Zyuz’kov, G.N., Danilets, M.G., Ligacheva, A.A. et al. Role of NF-κB-Dependent Signaling in the Growth Capacity of Mesenchymal Progenitor Cells Under the Influence of Basic Fibroblast Growth Factor . Bull Exp Biol Med 157, 353–356 (2014). https://doi.org/10.1007/s10517-014-2564-3

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  • DOI: https://doi.org/10.1007/s10517-014-2564-3

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