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Effects of Lys-Glu-Trp Peptide on Cell–Cell Interactions and Vascular Endothelium Proliferation under Normal Conditions and during Atherosclerosis

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The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell–cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp peptide in doses of 4 and 40 μg/ml promoted recovery of Cx37, Cx40, and VEGF expression in cultured endotheliocytes from the aorta of patients with atherosclerosis, which attests to vasoprotective effects of this agent.

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Authors and Affiliations

  1. Tsitomed Biomedical Research-and-Production Complex, St. Petersburg, Russia

    V. V. Malinin

  2. D. O. Ott Research Institute of Obstetrics and Gynecology, North-West Division of Russian Academy of Medical Sciences, St. Petersburg, Russia

    A. O. Durnova, V. O. Polyakova & I. M. Kvetnoi

Authors
  1. V. V. Malinin
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  2. A. O. Durnova
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  3. V. O. Polyakova
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  4. I. M. Kvetnoi
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Corresponding author

Correspondence to I. M. Kvetnoi.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 298-300, March, 2014

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Malinin, V.V., Durnova, A.O., Polyakova, V.O. et al. Effects of Lys-Glu-Trp Peptide on Cell–Cell Interactions and Vascular Endothelium Proliferation under Normal Conditions and during Atherosclerosis. Bull Exp Biol Med 157, 324–326 (2014). https://doi.org/10.1007/s10517-014-2556-3

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  • DOI: https://doi.org/10.1007/s10517-014-2556-3

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