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Study of Interactions between DNA and Tetrapeptides Study of Interactions between DNA and Tetrapeptides

  • BIOGERONTOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Tetrapeptide Lys-Glu-Asp-Trp is a mimetic of insulinotropic peptides and reduces the blood glucose level. This tetrapeptide increases the content of important factors of differentiation in endocrine pancreatic cells in vitro. Molecular modeling shows that this tetrapeptide can interact with not only minor, but also major groove of DNA molecule. The interaction with the major groove is more specific, because it depends on the primary sequences of the tetrapeptide and DNA. Sequence GGCAG is the putative binding site for the tetrapeptide.

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References

  1. V. Kh. Khavinson, A. O. Durnova, V. O. Polyakova, et al., Bull. Exp. Biol. Med., 154, No. 4, 501-504 (2012).

    Article  CAS  Google Scholar 

  2. V. N. Anisimov and V. Kh. Khavinson, Biogerontology, 11, No. 2, 139-149 (2010).

    Article  PubMed  CAS  Google Scholar 

  3. A. C. Cheng, W. W. Chen, C. N. Fuhrmann, and A. D. Frankel, J. Mol. Biol., 327, No. 4, 781-796 (2003).

    Article  PubMed  CAS  Google Scholar 

  4. A. Chung, F. Eudes, and Y.-S. Shim, IUBMB Life, 62, No. 3, 183-193 (2010).

    Article  CAS  Google Scholar 

  5. B. H. Geierstanger, M. Mrksich, P. B. Dervan, and D. E. Wemmer, Science, 266, 646-650 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. N. A. Halgren and R. B. Nachbar, J. Comput Chem., 17, 587-615 (1996).

    CAS  Google Scholar 

  7. H. Huang, I. D. Kozekov, A. Kozekova, et al., Biochemistry, 49, No. 29, 6155-6164 (2010).

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  8. V. Kh. Khavinson and V. V. Malinin, Gerontological Aspects of Genome Peptide Regulation, Basel (2005).

  9. V. Kh. Khavinson, A. Yu.Solov’ev, D. V. Zhilinskii, et al., Adv. Gerontol., 2, No. 4, 11-22 (2012).

    Article  Google Scholar 

  10. N. M. Luscombe, R. A. Laskowski, and J. M. Thornton, Nucleic Acids Res., 29, No. 13, 2860-2874 (2001).

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  11. P. E. MacDonald, W. El-kholy, M. J. Riedel, et al., Diabetes, 51, Suppl. 3, S434-S442 (2002).

    Article  PubMed  CAS  Google Scholar 

  12. Molecular Operating Environment; Chemical Computing Group Inc (2012) 1010 Sherbooke St. West, Suite No. 910, Montreal, QC, Canada, H3A 2R7.

  13. S. Ryu, S. Zhou, A. G. Ladurner, and R. Tjian, Nature, 397, 446-450 (1999).

    Article  PubMed  CAS  Google Scholar 

  14. S. Trabulo, A. L. Cardoso, M. Mano, and M. C. PedrosoDelima, Pharmaceuticals, 3, No. 4, 961-993 (2010).

    Article  CAS  Google Scholar 

  15. V. Kh. Khavinson, V. V. Malinin, E. I. Grigoriev, and G. A. Ryzhak, USA Patent US 7,491,703. Tetrapeptide regulating blood glucose level in diabetes mellitus, (17.02.2009).

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Sciences, St. Petersburg, Russia

    S. I. Tarnovskaya & V. Kh. Khavinson

  2. Center for Advanced Studies, St. Petersburg State Polytechnic University, Russian Academy of Sciences, St. Petersburg, Russia

    P. P. Yakutseni

  3. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. Kh. Khavinson

Authors
  1. S. I. Tarnovskaya
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  2. P. P. Yakutseni
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  3. V. Kh. Khavinson
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Correspondence to S. I. Tarnovskaya.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 637-641, November, 2013

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Tarnovskaya, S.I., Yakutseni, P.P. & Khavinson, V.K. Study of Interactions between DNA and Tetrapeptides Study of Interactions between DNA and Tetrapeptides. Bull Exp Biol Med 156, 689–693 (2014). https://doi.org/10.1007/s10517-014-2426-z

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  • DOI: https://doi.org/10.1007/s10517-014-2426-z

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