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Effect of Galectin-1 on Apoptosis of CD4+ Lymphocytes Differentiated In Vitro Towards Regulatory T Cells

  • IMMUNOLOGY AND MICROBIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of galectin-1 on apoptosis of CD4+ lymphocytes intact and in vitro differentiated towards regulatory T cells. An increase in the content of apoptotic CD4+ lymphocytes was observed after exposure of intact cells with 15 ng/ml galectin-1 and after exposure of regulatory T cells with 10 and 15 ng/ml galectin-1. Apoptosis of regulatory T cells induced by galectin-1 was accompanied by an increase in the content of proapoptotic protein Bad.

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Authors and Affiliations

  1. Department of Molecular Medicine and Clinical Laboratory Diagnostics, Siberian State Medical University, the Ministry of Health Care and Social Development, Tomsk, Russia

    O. A. Vasil’eva, N. V. Andreeva, E. G. Starikova, L. A. Tashireva, T. S. Prokhorenko, A. P. Zima & N. V. Ryazantseva

  2. Department of Pathophysiology, Siberian State Medical University, the Ministry of Health Care and Social Development, Tomsk, Russia

    V. D. Yakushina & V. V. Novitskii

  3. Research and Educational Center of Molecular Medicine, Siberian State Medical University, the Ministry of Health Care and Social Development, Tomsk, Russia

    V. D. Yakushina, O. A. Vasil’eva & N. V. Ryazantseva

Authors
  1. V. D. Yakushina
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  2. O. A. Vasil’eva
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  3. V. V. Novitskii
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  4. N. V. Andreeva
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  5. E. G. Starikova
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  6. L. A. Tashireva
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  7. T. S. Prokhorenko
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  8. A. P. Zima
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  9. N. V. Ryazantseva
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Corresponding author

Correspondence to V. D. Yakushina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 616-619, November, 2013

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Yakushina, V.D., Vasil’eva, O.A., Novitskii, V.V. et al. Effect of Galectin-1 on Apoptosis of CD4+ Lymphocytes Differentiated In Vitro Towards Regulatory T Cells. Bull Exp Biol Med 156, 669–672 (2014). https://doi.org/10.1007/s10517-014-2422-3

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  • DOI: https://doi.org/10.1007/s10517-014-2422-3

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