The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for the choice of material, carrier for the drug (myramistin hydrochloride), was evaluated. Due to use of this method, the volume of experimental studies could be reduced and the data systematized.
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V. V. Akopova, A. V. Pogrebnyak, L. V. Pogrebnyak, and E. T. Zhilyakova, Nauchn. Vedomosti Belgorodsk. Univer., Ser. Medicine. Pharmacy, 22, No. 16/2, 63-68 (2011).
E. T. Zhilyakova, O. O. Novikov, V. V. Akopova, et al., Nauchn. Vedomosti Belgorodsk. Univer., Ser. Medicine. Pharmacy, 22, No. 12/2, 73-76 (2010).
A. V. Pogrebnyak, Molecular Simulation and Design of Bioactive Substances [in Russian], Rostov-on-Don (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 260-264, August, 2013
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Zhilyakova, E.T., Novikov, O.O. & Akopova, V.V. Soft Contact Lenses as Prospective Transport Systems for Ophthalmology. Bull Exp Biol Med 156, 290–294 (2013). https://doi.org/10.1007/s10517-013-2332-9
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DOI: https://doi.org/10.1007/s10517-013-2332-9