Skip to main content
SpringerLink
Log in

Morphometric Evaluation of Vascularization of Hepatic Focal Nodular Hyperplasia

  • MORPHOLOGY AND PATHOMORPHOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Comparative morphometric evaluation of the quantitative characteristics of vessels in hepatic focal nodular hyperplasia tissue was carried out on preparations stained with hematoxylin and eosin and by immunohistochemical detection of CD34 and CD105. Analysis of histological preparations stained with hematoxylin and eosin allowed the most ample characterization. Immunohistochemical detection of CD34 promoted better visualization of endotheliocytes, but just some sinusoids in the preparations were labeled. Expression of CD105 visualized the active endothelial cells and hence, helped to evaluate neoangiogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. U. N. Tumanova, G. G. Karmazanovskii, and A. I. Shchyogolev, Med. Vizualizatsiya, No. 1, 52-58 (2013).

  2. W. M. Coston, S. Loera, S. K. Lau, et al., Am. J. Surg. Pathol., 32, No. 3, 433-444 (2008).

    Article  PubMed  Google Scholar 

  3. O. N. El-Assal, A. Yamanoi, Y. Soda, et al., Hepatology, 27, No. 6, 1554-1562 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. J. Folkman, J. Natl. Cancer Inst., 82, No. 1, 4-6 (1990).

    Article  CAS  PubMed  Google Scholar 

  5. J. W. Ho, R. T. Poon, C. K. Sun, et al., World J. Gastroenterol., 11, No. 2, 176-181 (2005).

    CAS  PubMed  Google Scholar 

  6. O. Matsui, M. Kadoya, T. Kameyama, et al., Radiology, 178, No. 2, 493-497 (1991).

    CAS  PubMed  Google Scholar 

  7. P. Ruck, J. C. Xiao, and E. Kaiserling, Arch. Pathol. Lab. Med., 119, No. 2, 173-178 (1995).

    CAS  PubMed  Google Scholar 

  8. S. Sharma, M. C. Sharma, and C. Sarkar, Histopathology, 46, No. 5, 481-489 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. A. I. Shchyogolev, E. A. Dubova, and U. N. Tumanova, Bull. Exp. Biol. Med., 153, No. 4, 490-494 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. P. Tátrai, A. Somorácz, E. Batmunkh, et al., Am. J. Surg. Pathol., 33, No. 6, 874-885 (2009).

    Article  PubMed  Google Scholar 

  11. I. Theuerkauf, H. Zhou, and H. P. Fischer, Virchows Arch., 438, No. 5, 498-504 (2001).

    Article  CAS  PubMed  Google Scholar 

  12. P. B. Vermeulen, G. Gasparini, S. B. Fox, et al., Eur. J. Cancer, 38, No. 12, 1564-1579 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. I. R. Wanless, C. Mawdsley, and R. Adams, Hepatology, 5, No. 6, 1194-1200 (1985).

    Article  CAS  PubMed  Google Scholar 

  14. WHO Classification of Tumors of the Digestive System, Eds. N. D. Theise et al., Lyon (2010), P. 205-216.

  15. Z. F. Yang and R. T. Poon, Anat. Rec. (Hoboken), 291, No. 6, 721-734 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    A. I. Shchyogolev, U. N. Tumanova & E. A. Dubova

Authors
  1. A. I. Shchyogolev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. N. Tumanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. A. Dubova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. I. Shchyogolev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 235-239, August, 2013

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shchyogolev, A.I., Tumanova, U.N. & Dubova, E.A. Morphometric Evaluation of Vascularization of Hepatic Focal Nodular Hyperplasia. Bull Exp Biol Med 156, 266–270 (2013). https://doi.org/10.1007/s10517-013-2327-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-013-2327-6

Key Words

Search

Navigation