In chronic experiments on rabbits, the effect of electric stimulation of the hunger center in the lateral hypothalamus on myoelectric activity of the fundal and antral parts of the stomach was studied under conditions of hunger and satiation in the absence of food. Stimulation of the lateral hypothalamus in rabbits subjected to 24-h food deprivation and in previously fed rabbits produced incessant seeking behavior, which was followed by reorganization of the structure of temporal organization of slow wave electric activity of muscles of the stomach body and antrum specific for hungry and satiated animals. Increased hunger motivation during electric stimulation of the lateral hypothalamus manifested in the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles in rabbits subjected to 24-h food deprivation in the replacement of bimodal distribution of slow wave periods to a trimodal type typical of 2-day deprivation, while transition from satiation to hunger caused by electric stimulation of the lateral hypothalamus was associated with a shift from monomodal distributions of slow wave periods to a bimodal type typical of 24-h deprivation. Reorganization of the structure of temporal organization of slow wave electric activity of the stomach body and antrum muscles during electric stimulation of the lateral hypothalamus was determined by descending inhibitory influences of food motivational excitation on activity of the myogenic pacemaker of the lesser curvature of the stomach.
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References
Yu. P. Ignatova and A. A. Kromin, Bull. Exp. Biol. Med., 149, No. 6, 671-676 (2010).
Patent of Russian Federation No. 2290883. A Technique of Anchoring of Electromyographic Electrodes to Smooth Muscles of Gastrointestinal Tract in Experiment. A. A. Kromin, O. Yu. Zenina, Bull. Izobr. Poleznye Modeli, No. 1, Pt. I, p. 166 (2007). Published 10.01.2007.
Patent of Russian Federation No. 52562. Electromyographic Bipolar Silver Spherical Electrode. A. A. Kromin, Yu. P. Ignatova, O. Yu. Zenina. Bull. Izobr. Poleznye Modeli, No. 10, P. 3, 809 (2006). Published 10.04.2006.
Patent No. 2368402. A Technique for Inducing of Behavioral Response in Chronic Experiment and a Device for Inducing of Behavioral Food Responses in Chronic Experiment. A. A. Kromin, Yu. P. Ignatova, E. P. Sergeeva, O. Yu. Zenina. Bull. Izobr. Poleznye Modeli, No. 27 (2009). Published 27.09.2009.
K. V. Sudakov. Dominating Motivation [in Russian], Moscow (2004).
C. V. Grijalva and D. Novin., Ann. N. Y. Acad. Sci., 597, 207-222 (1990).
J. D. Huizinga, L. Thuneberg, J. M. Vanderwinden, and J. J. Rumessen, Trends. Pharmacol. Sci., 18, No. 10, 393-403 (1997).
C. Jiang, R. Fogel, and X. Zhang, Brain Res., 980, No. 1, 31-47 (2003).
Y. Peng and K. W. Lin, Sheng Li Xue Bao., 51, No. 5, 557-563 (1999).
K. M. Sanders, Gastroenterology, 111, No. 2, 492-515 (1996).
M. Welkenhuysen, K. Van Kuyck, J. Das, et. al., Neurosurg. Focus., 25, No. 1, E7 (2008).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 5, pp. 536-542, May, 2013
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Kromin, A.A., Zenina, O.Y. Effects of Electric Stimulation of the Hunger Center in the Lateral Hypothalamus on Slow Electric Activity and Spike Activity of Fundal and Antral Stomach Muscles in Rabbits under Conditions of Hunger and Satiation. Bull Exp Biol Med 155, 591–597 (2013). https://doi.org/10.1007/s10517-013-2202-5
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DOI: https://doi.org/10.1007/s10517-013-2202-5