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Anti-Infl ammatory Activity of TS-13, ARE-Inducing Phenol Antioxidant

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Bulletin of Experimental Biology and Medicine Aims and scope

The protective effect of water-soluble TS-13 monophenol inducing the antioxidant-responsive element (ARE) system was studied on the models of acute inflammation. Intragastric administration of TS-13 to rats significantly reduced the severity of acute aseptic inflammation induced by intravenous injection of zymosan particles: granulocyte blood count and volume density of infiltrates in the liver decreased on day 3, spontaneous production of activated oxygen metabolites and respiratory burst in blood granulocytes decreased on days 2 and 3. A single dose of TS-13 improved survival of mice with endotoxin shock induced by intraperitoneal injection of E. coli LPS. These results confirmed high anti-inflammatory activity of TS-13.

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Authors and Affiliations

  1. Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    E. B. Menshchikova, V. O. Tkachev, N. K. Zenkov, A. E. Lemza & T. V. Sharkova

  2. Novosibirsk State Pedagogical University, Novosibirsk, Russia

    N. V. Kandalintseva

Authors
  1. E. B. Menshchikova
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  2. V. O. Tkachev
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  3. N. K. Zenkov
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  4. A. E. Lemza
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  5. T. V. Sharkova
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  6. N. V. Kandalintseva
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Corresponding author

Correspondence to E. B. Menshchikova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 344–348, March, 2013

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Menshchikova, E.B., Tkachev, V.O., Zenkov, N.K. et al. Anti-Infl ammatory Activity of TS-13, ARE-Inducing Phenol Antioxidant. Bull Exp Biol Med 155, 366–369 (2013). https://doi.org/10.1007/s10517-013-2155-8

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  • DOI: https://doi.org/10.1007/s10517-013-2155-8

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