Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that of ortho-aminoazotoluene in suckling mice. Both 4-aminoazobenzene and ortho-aminoazotoluene exhibited mutagenic activity in Ames’ test in vitro on S. typhimurium TA 98 strain with activation with liver enzymes; this mutagenic activity was similarly suppressed by adding pentachlorophenol into activation medium. Induction of xenobiotic metabolism enzymes, stimulating the mutagenic activity of ortho-aminoazotoluene, suppressed its carcinogenic effect on mouse liver. Hence, ortho-aminotoluene (the initial compound), but not its mutagenic metabolites, was the direct active hepatocarcinogen for mice.
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References
G. I. Abelev, Biokhimiya, 65, No. 1, 127–138 (2000).
G. I. Abelev and T. L. Eraizer, Ibid., 73, No. 5, 605–618 (2008).
N. A. Bolotina, A. V. Gaspar’yan, T. K. Dubovaya, et al., Ibid., 72, No. 5, 682–689 (2007).
E. V. Gorshkova, V. I. Kaledin, V. F. Kobzev, and T. I. Merkulova, Ibid., 70, No. 10, 1432–1437 (2005).
V. I. Kaledin, E. A. Vasyunina, L. P. Ovchinnikova, et al., Vestn. VOGIS, Nos. 21–22, 11–19 (2003).
V. I. Kaledin and S. I. Ilnitskaya, Vopr. Onkol., 57, No. 2, 216–220 (2011).
V. I. Kaledin, S. I. Ilnitskaya, and N. V. Baginskaya, Ibid., 56, No. 2, 196–200 (2010).
A. V. Lichtenstein, Biokhimiya, 74, No. 4, 437–446 (2009).
L. P. Ovchinnikova, U. N. Rotskaya, E. A. Vasyunina, et al., Bioorgan. Khim., 35, No. 3, 417–427 (2009).
I. F. Seits and P. G. Knyazev, Molecular Oncology [in Russian], Leningrad (1986).
V. S. Turusov, G. A. Belitsky, L. I. Pylev, and V. A. Koblyakov, Carcinogenesis [in Russian], Moscow (2004), pp. 204–225.
K. B. Delclos, E. S. Miller, J. A. Miller, and A. Liem, Carcinogenesis, 7, No. 2, 277–287 (1986).
F. F. Kadlubar, Chem. Res. Toxicol., 14, No. 4, 335–337 (2001).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 623–628, November, 2012
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Ovchinnikova, L.P., Bogdanova, L.A. & Kaledin, V.I. Mutagenic Activation Reduces Carcinogenic Activity of Ortho-Aminoazotoluene for Mouse Liver. Bull Exp Biol Med 154, 664–668 (2013). https://doi.org/10.1007/s10517-013-2025-4
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DOI: https://doi.org/10.1007/s10517-013-2025-4