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Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in a dose of 1 mg/kg 4 and 24 h after surgery and 24 h before testing the CNS function on days 3, 7, and 14 prevent death of experimental animals, reduce the neurological deficit, and normalized behavior.

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    V. A. Kraineva, T. A. Gudasheva, S. O. Kotelnikova, T. A. Antipova & S. B. Seredenin

Authors
  1. V. A. Kraineva
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  2. T. A. Gudasheva
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  3. S. O. Kotelnikova
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  4. T. A. Antipova
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  5. S. B. Seredenin
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Corresponding author

Correspondence to V. A. Kraineva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 11, pp. 598–601, November, 2012

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Kraineva, V.A., Gudasheva, T.A., Kotelnikova, S.O. et al. Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats. Bull Exp Biol Med 154, 642–644 (2013). https://doi.org/10.1007/s10517-013-2020-9

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  • DOI: https://doi.org/10.1007/s10517-013-2020-9

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