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Comparison of the Pharmacological Effects of Dimeric Dipeptide Nerve Growth Factor Mimetic GK-2 and Mexidol on the Model of Ischemic Stroke in Rats

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We compared the effects of GK-2 (dimeric dipeptide mimetic of nerve growth factor) and Mexidol (standard preparation for the therapy of stroke) on rat model of transient occlusion of the middle cerebral artery. GK-2 and Mexidol were administered intraperitoneally in the most active doses (1 and 100 mg/kg, respectively) 6 h after surgery and then once a day for 6 days. The preparations reduced the volume of cerebral infarction (by 60 and 30%, respectively). At the same time, GK-2 had a pronounced and statistically more reliable effect in a dose that is lower by two orders of magnitude. In addition, GK-2 significantly reduced the neurological deficit in the limb placement test, while Mexidol was ineffective in this test.

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Authors and Affiliations

  1. Laboratory of Peptide Bioregulation, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    P. Yu. Povarnina, A. A. Volkova & T. A. Gudasheva

  2. Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    S. B. Seredenin

Authors
  1. P. Yu. Povarnina
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  2. A. A. Volkova
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  3. T. A. Gudasheva
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  4. S. B. Seredenin
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Corresponding author

Correspondence to P. Yu. Povarnina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 164, No. 8, pp. 201-204, August, 2017

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Povarnina, P.Y., Volkova, A.A., Gudasheva, T.A. et al. Comparison of the Pharmacological Effects of Dimeric Dipeptide Nerve Growth Factor Mimetic GK-2 and Mexidol on the Model of Ischemic Stroke in Rats. Bull Exp Biol Med 164, 173–176 (2017). https://doi.org/10.1007/s10517-017-3951-3

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  • DOI: https://doi.org/10.1007/s10517-017-3951-3

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