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Effect of Supernatant from Fibroblasts from the Progeny of Female Rats with Chronic Liver Disease of Different Origin on the Morphology and Function of Cultured Peritoneal Macrophages

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We studied the effects of supernatant from ovarian fibroblasts derived from the progeny of female rats with experimental chronic liver disease of different genesis on the function of cultured allogenic peritoneal macrophages. Addition of fibroblast supernatant derived from animals with liver disease to the culture medium suppressed the function of peritoneal macrophages from intact newborn rats, which manifested in reduction of the adhesion characteristics and decrease of their phagocytic parameter and phagocytic index.

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Authors and Affiliations

  1. Department of Histology, Embryology, and Cytology, Chelyabinsk State Medical Academy, Chelyabinsk, Russia

    G. V. Bryukhin & I. V. Zubarev

Authors
  1. G. V. Bryukhin
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  2. I. V. Zubarev
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Correspondence to I. V. Zubarev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 511–513, October, 2012

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Bryukhin, G.V., Zubarev, I.V. Effect of Supernatant from Fibroblasts from the Progeny of Female Rats with Chronic Liver Disease of Different Origin on the Morphology and Function of Cultured Peritoneal Macrophages. Bull Exp Biol Med 154, 512–514 (2013). https://doi.org/10.1007/s10517-013-1990-y

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  • DOI: https://doi.org/10.1007/s10517-013-1990-y

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