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Changes in the Circulatory and Lymphatic Systems of Internal Genitals in Female Rats after Intravenous and Lymphotropic Administration of Multipotent Mesenchymal Stem Cells and Products Secreted by These Cells

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of intravenous and lymphotropic administration of bone marrow multipotent mesenchymal stromal cells and products secreted by these cells into conditioned medium on the blood and lymph circulation in the uterus and ovaries, as well as on folliculogenesis in female Wistar rats. It was shown that stromal cells and conditioned media of these cells administered via both routes lead to an increase in the number and diameter of blood vessels in the uterine wall and in the cortical layer of the ovaries. Neither mesenchymal stromal cells, not conditioned media affected the ovarian follicular apparatus.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    T. I. Dergacheva, A. V. Shurlygina, E. V. Starkova, O. V. Poveshchenko, V. V. Klimontov & V. I. Konenkov

Authors
  1. T. I. Dergacheva
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  2. A. V. Shurlygina
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  3. E. V. Starkova
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  4. O. V. Poveshchenko
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  5. V. V. Klimontov
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  6. V. I. Konenkov
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Corresponding author

Correspondence to A. V. Shurlygina.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 3, pp. 203-207, September, 2019

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Dergacheva, T.I., Shurlygina, A.V., Starkova, E.V. et al. Changes in the Circulatory and Lymphatic Systems of Internal Genitals in Female Rats after Intravenous and Lymphotropic Administration of Multipotent Mesenchymal Stem Cells and Products Secreted by These Cells. Bull Exp Biol Med 168, 168–172 (2019). https://doi.org/10.1007/s10517-019-04669-9

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  • DOI: https://doi.org/10.1007/s10517-019-04669-9

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