Expression of differentiation markers was found to be reduced during ageing of pancreatic cells. Tetrapeptide pancragen stimulates the expression of differentiation factors of acinar (Pdx1, Ptfl a) and islet of Langerhans (Pdx1, Pax6, Pax4, Foxa2, NKx2.2) cells in “young” and “aged” cultures. Differentiation of acinar and islet pancreatic cells induced by pancragen can be a mechanism underlying its anti-diabetic and anti-inflammatory effects. Thus, transcription factors that regulate differentiation of pancreatic cells are a pharmacological target for pancragen, which allows considering it as an effective tool in the treatment of diabetes mellitus and pancreatitis.
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References
B. Alberto, E. W. Gregg, R. B. Gerzoff, et al., Diabetes Care, 35, No. 4, 738–740 (2012).
T. Crnogorac-Jurcevic, E. Efthimiou, P. Capelli, et al., Oncogene, 20, No. 50, 7437–7446 (2001).
M. J. Doyle and L. Sussel, Diabetes, 56, No. 8, 1999–2007 (2007).
L. I. Fedoreyeva, I. I. Kireev, V. Kh. Khavinson, and B. F. Vanyushin, Biochemistry (Moscow), 76, No. 11, 1210–1219 (2011).
M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, et al., Endocrine Rev., 28, No. 6, 685–705 (2007).
V. Kh. Khavinson, M. M. G. Gapparov, N. E. Sharanova, et al., Byull. Eksp. Biol. Med., 149, No. 3, 351–353 (2010).
V. Kh. Khavinson, V. V. Malinin, E. I. Grigoriev, and G. A. Ryzhak, Tetrapeptide regulating blood glucose level in diabetes mellitus. USA Patent US 7,491,703, 17.02.2009.
O. V. Korkushko, V. Kh. Khavinson, V. B. Shatilo, et al., Byull. Eksp. Biol. Med., 151, No. 4, 454–456 (2011).
C. S. Lee, N. J. Sund, R. Behr, et al., Dev. Biol., 278, No. 2, 484–495 (2005).
G. S. Sellick, K. T. Barker, I. Stolte-Dijkstra, et al., Nat. Genet., 36, No. 12, 1301–1305 (2004).
B. G. Slavin and S. P. Lerner, Anat. Res., 228, No. 1, 53–57 (1990).
L. St-Onge, B. Sosa-Pineda, K. Chowdhury, et al., Nature, 387, 406–409 (1997).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 498–501, October, 2012
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Khavinson, V.K., Durnova, A.O., Polyakova, V.O. et al. Effects of Pancragen on The Differentiation of Pancreatic Cells During Their Ageing. Bull Exp Biol Med 154, 501–504 (2013). https://doi.org/10.1007/s10517-013-1987-6
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DOI: https://doi.org/10.1007/s10517-013-1987-6