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Oxygen Tension in Rat Brain during Hypoxia

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

An Erratum to this article was published on 17 March 2013

Critical value of oxygen tension (Po2) and cerebral blood flow in the striatum for seizure appearance during hyperbaric oxygenation (5 ATA) were determined in awake Wistar rats. Seizure activity was observed at Po2=1030±102 mm Hg. A relationship between brain Po2 and blood flow was revealed at different regimens of hyperbaric oxygenation using a mathematical model. Comparison of experimental data and mathematical model showed that seizureinducing levels of Po2 during hyperbaric oxygenation at 4, 5, and 6 ATA can be achieved after increasing blood flow by 1.5-3.0, 1.2-2.0, and 0.8-1.1, respectively.

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Authors and Affiliations

  1. Laboratory for Hyperbaric Physiology, I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, Sankt-Petersburg, Russia

    A. N. Moskvin

  2. Laboratory for Comparative Genetics of Behavior, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Sankt-Petersburg, Russia

    Yu. I. Luchakov

Authors
  1. A. N. Moskvin
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  2. Yu. I. Luchakov
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Correspondence to A. N. Moskvin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 429–431

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Moskvin, A.N., Luchakov, Y.I. Oxygen Tension in Rat Brain during Hypoxia. Bull Exp Biol Med 154, 435–437 (2013). https://doi.org/10.1007/s10517-013-1970-2

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  • DOI: https://doi.org/10.1007/s10517-013-1970-2

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