Experiments were performed on Wistar rats divided into three groups: group 1 (experimental group) consisted of rats subjected to hypoxia and treated with Salifen (15 mg/kg for 14 days); group 2 (controls) consisted of rats subjected to hypoxia but not treated; group 3 consisted of intact animals (each group included 8–10 animals). Light and electron microscopy methods were used to study the effects of Salifen on the structural characteristics of elements of the blood-brain barrier (BBB) of the neocortex in rats after exposure to hypoxia during the early postnatal period – on day 2 of life (a model of premature birth in humans). The results showed that Salifen had positive actions on the state of the microcirculatory bed after perinatal hypoxia, particularly in relation to state of endotheliocytes. Salifen was found to take active part in compensatory-adaptive reactions of the BBB in response to hypoxia; these experiments identified potential for further studies of the protective properties of Salifen.
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Translated from Morfologiya,, Vol. 148, No. 6, pp. 34–37, November–December, 2015.
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Otellin, V.A., Khozhai, L.I. & Tyurenkov, I.N. Actions of Perinatal Hypoxia on the Structure of the Blood-Brain Barrier in Rats after Administration of Salifen. Neurosci Behav Physi 46, 879–881 (2016). https://doi.org/10.1007/s11055-016-0326-6
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DOI: https://doi.org/10.1007/s11055-016-0326-6