Bile peritonitis is associated with endotoxemia, endothelial dysfunction, and increased level of pro-inflammatory cytokines. Under these conditions, serum concentration of NO metabolites (nitrate/nitrite ratio) and NO production by platelets significantly increase in animals with bile peritonitis, which reflects the development of inflammatory process and its antithrombotic activity, respectively. At the same time, platelet adhesion to lymphocytes increased in animals with bile peritonitis. The observed effect was confirmed by a direct correlation between the adhesion activity of lymphocytes to platelets and the content of desquamated endotheliocytes. This phenomenon played a crucial role in the development of protective and reparative processes in the damaged surface of vessel wall.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 10, pp. 421–424, October, 2012
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Petrosyan, E.A., Tereshenko, O.A., Botashev, A.A. et al. Role of Endothelial Dysfunction and Lymphocyte-Platelet Adhesion in the Pathogenesis of Bile Peritonitis. Bull Exp Biol Med 154, 428–430 (2013). https://doi.org/10.1007/s10517-013-1968-9
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DOI: https://doi.org/10.1007/s10517-013-1968-9