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Chromogranin Location in the Adrenal Glands of ISIAH Rats

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Comparative immunohistochemical and electron microscopic study of the adrenals from hypertensive ISIAH rats and normotensive WAG rats (control) showed a more intense reaction to chromogranin A in the ISIAH adrenal in comparison with the control. Electron microscopy and morphometric analysis showed high volume and numerical densities of the secretory granules in chromaffin cells of hypertensive rats. The results indicate stimulation of the adrenal medullary substance in ISIAH rats. Presumably, intensive accumulation of chromogranin A and secretory granules in chromaffin cells of hypertensive rats reflects a certain imbalance of chromogranin A and catecholamines biogenesis, this, in turn, leading to stable stimulation of the sympathoadrenal component and higher stress sensitivity of these animals.

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Authors and Affiliations

  1. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    I. I. Buzueva, E. E. Filyushina, M. D. Shmerling & G. S. Yakobson

  2. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. L. Markel

Authors
  1. I. I. Buzueva
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  2. E. E. Filyushina
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  3. M. D. Shmerling
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  4. A. L. Markel
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  5. G. S. Yakobson
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Correspondence to I. I. Buzueva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 380-383, September, 2012

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Buzueva, I.I., Filyushina, E.E., Shmerling, M.D. et al. Chromogranin Location in the Adrenal Glands of ISIAH Rats. Bull Exp Biol Med 154, 393–395 (2013). https://doi.org/10.1007/s10517-013-1958-y

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  • DOI: https://doi.org/10.1007/s10517-013-1958-y

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