Skip to main content
SpringerLink
Log in

Morphofunctional Characteristics of Fibroblasts and Fibrogenesis in the Lungs of Mice Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Virus

  • VIROLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Mice C57Bl/6 were intranasally infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The expression of influenza A virus antigen in the lung interstitium fibroblasts was recorded during all periods of the study (on days 1-14 after infection), the maximum expression on days 1 and 3. On day 1, the volume density of collagen fibers in the lungs was 3-fold higher than in intact animals; by day 14 it increased almost 15-fold. The numerical density of PCNA+ fibroblasts increased almost 2-fold from day 1 to day 10; “fibroplastic activity” of fibroblasts increased more than 3-fold.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. V. Kovner, A. G. Anikina, O. V. Potapova, et al., Bull. Eksper. Biol., 153, No. 2, 196-199 (2012).

    Google Scholar 

  2. O. V. Potapova, V. A. Shkurupy, T. V. Sharkova, et al., Ibid., 150, No. 12, 650-653 (2010).

    Google Scholar 

  3. T. V. Sologub, M. Yu. Ledvanov, and V. P. Malyi, Uspekhi Sovrem. Estestvoznan., No. 12, 29-33 (2009).

    Google Scholar 

  4. A. M. Shestopalov, K. A. Sharshov, A. V. Zaikovskaya, et al., Bull. Eksp. Biol. Med., 146, No. 9, 317-320 (2008).

    Google Scholar 

  5. L. V. Shestopalova, V. A. Shkurupy, T. V. Sharkova, et al., Vestn. NGU, 6, No. 3, 3-9 (2008).

    Google Scholar 

  6. V. A. Shkurupy, Tuberculous Granulomatosis. Cytophysiology and Addressed Therapy [in Russian], Moscow (2007).

  7. T. Daidoji, T. Koma, A. Du, et al., J. Virol., 82, No. 22, 11,294-11,307 (2008).

    Article  CAS  Google Scholar 

  8. Y. Hu, Y. Jin, D. Han, et al., Ibid., 86, No. 6, 3347-3356 (2012).

    CAS  Google Scholar 

  9. C. Korteweg and J. Gu, Am. J. Pathol., 172, No. 5, 1155-1170 (2008).

    Article  PubMed  CAS  Google Scholar 

  10. J. Qiao, M. Zhang, J. Bi, et al., Respir. Res., 10, 107-112 (2009).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    A. G. Anikina, O. V. Potapova & V. A. Shkurupy

Authors
  1. A. G. Anikina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. V. Potapova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. A. Shkurupy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. V. Potapova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 346-349, September, 2012

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anikina, A.G., Potapova, O.V. & Shkurupy, V.A. Morphofunctional Characteristics of Fibroblasts and Fibrogenesis in the Lungs of Mice Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Virus. Bull Exp Biol Med 154, 361–364 (2013). https://doi.org/10.1007/s10517-013-1951-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-013-1951-5

Keywords

Search

Navigation