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Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the secretory function of the liver and bone marrow microenvironment cells under conditions of chronic CCl4-induced hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was observed. In situ binding of stem cells by bone marrow elements increased due to production of various cooperation and adhesion factors against the background of reduced SDF-1 secretion.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, G. N. Zyuz’kov, R. V. Gurto, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, A. V. Chaikovskiy, T. S. Markova, E. V. Simanina, L. A. Stavrova, M. Yu. Minakova & V. I. Agafonov

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  1. A. M. Dygai
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  2. G. N. Zyuz’kov
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  3. R. V. Gurto
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  4. V. V. Zhdanov
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  5. E. V. Udut
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  6. L. A. Miroshnichenko
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  7. A. V. Chaikovskiy
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  8. T. S. Markova
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  9. E. V. Simanina
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  10. L. A. Stavrova
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  11. M. Yu. Minakova
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  12. V. I. Agafonov
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 278–281, September, 2012

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Dygai, A.M., Zyuz’kov, G.N., Gurto, R.V. et al. Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis. Bull Exp Biol Med 154, 303–305 (2013). https://doi.org/10.1007/s10517-013-1936-4

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  • DOI: https://doi.org/10.1007/s10517-013-1936-4

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