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Effect of Selective Stimulation of Muscarinic M3 Cholinoceptors on Electrical and Contractile Activity of Rat Ventricular Myocardium

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of selective activation of muscarinic M3 receptors on electrical activity in the isolated preparation of rat ventricular myocardium as well as contractile activity of the left ventricle of Langendorff-perfused isolated heart. Application of muscarinic agonist pilocarpine (10−5 M) against the background of selective blockade of subtype 2 muscarinic receptors with methoctramine (10−7 M) markedly shortened the duration of action potentials in the isolated ventricular myocardium and reduced the amplitude and maximum rates of left-ventricular pressure rise and decay in the isolated heart paced at a fixed rate. All these effects were significantly suppressed by selective M3 receptor blocker 4-DAMP (10−8 M), which attested to the involvement of M3 muscarinic receptors.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia

    D. V. Abramochkin & S. V. Tapilina

Authors
  1. D. V. Abramochkin
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  2. S. V. Tapilina
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  3. G. S. Sukhova
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Correspondence to D. V. Abramochkin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 9, pp. 268–272, September, 2012

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Abramochkin, D.V., Tapilina, S.V. & Sukhova, G.S. Effect of Selective Stimulation of Muscarinic M3 Cholinoceptors on Electrical and Contractile Activity of Rat Ventricular Myocardium. Bull Exp Biol Med 154, 295–298 (2013). https://doi.org/10.1007/s10517-013-1934-6

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  • DOI: https://doi.org/10.1007/s10517-013-1934-6

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