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Effect of Hyaluronate-Endo-β-N-Acetylhexosaminidase Pegylated by Electron Beam Synthesis Nanotechnology on the Formation of Hematological Shifts in Chronic Hepatitis

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of mobilization of bone marrow multipotent stem cells induced by intragastric administration of pegylated hyaluronate-endo-β-N-acetylhexosaminidase (Peg-HEAHA) on hemopoiesis under conditions of experimental chronic hepatitis. Peg-HEAHA increased the counts of hemopoietic precursors in the hemopoietic tissue against the background of their decelerated maturation. This was paralleled by a short-term decrease in the count of neutrophilic granulocyte in the bone marrow and a slight increase of neutrophil count in the peripheral blood.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, G. N. Zyuz’kov, R. V. Gurto, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, L. A. Stavrova, A. V. Chaikovskii, T. S. Markova & M. Yu. Minakova

  2. Scientific Future Management, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev, P. G. Madonov & D. N. Kinsht

Authors
  1. A. M. Dygai
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  2. G. N. Zyuz’kov
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  3. R. V. Gurto
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  4. V. V. Zhdanov
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  5. E. V. Udut
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  6. L. A. Miroshnichenko
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  7. E. V. Simanina
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  8. L. A. Stavrova
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  9. A. V. Chaikovskii
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  10. T. S. Markova
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  11. M. Yu. Minakova
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  12. A. V. Artamonov
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  13. A. A. Bekarev
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  14. P. G. Madonov
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  15. D. N. Kinsht
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Corresponding author

Correspondence to G. N. Zyuz’kov.

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Dygai, A.M., Zyuz’kov, G.N., Gurto, R.V. et al. Effect of Hyaluronate-Endo-β-N-Acetylhexosaminidase Pegylated by Electron Beam Synthesis Nanotechnology on the Formation of Hematological Shifts in Chronic Hepatitis. Bull Exp Biol Med 154, 278–282 (2012). https://doi.org/10.1007/s10517-012-1930-2

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  • DOI: https://doi.org/10.1007/s10517-012-1930-2

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