The effects of hydrophilic synthetic antioxidant TC-13 sodium (3’-(3’-tert-butyl-4’-hydroxyphenyl) propylthiosulfonate on survival of various strains of Drosophila melanogaster were studied under conditions of oxidative stress induced with H2O2 and paraquat. In a concentration of 1%, TC-13 signifi cantly improved survival of Canton S males treated with H2O2 and in a concentration of 0.2% it improved survival of H2O2-stressed Oregon R females. The protective effect of the antioxidant under conditions of paraquat-induced stress was observed in Canton S females and Oregon R fl ies of both genders. Addition of T-13 to diets led to prolongation of the maximum lifespan of insects in the majority of the experiment variants. A relationship between the protective effects of TC-13 and the genotype, gender, and environmental conditions was detected.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 226-230, August, 2012
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Menshchikova, E.B., Wisman, N.Y., Zenkov, N.K. et al. ARE-Inducing Phenol Antioxidant TC-13 Improves Survival of Drosophila Melanogaster in Oxidative Stress. Bull Exp Biol Med 154, 260–264 (2012). https://doi.org/10.1007/s10517-012-1926-y
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DOI: https://doi.org/10.1007/s10517-012-1926-y