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Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensifi cation of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, R. V. Gurto, L. A. Miroshnichenko, E. V. Simanina, T. Iu. Khrichkova, L. A. Stavrova, A. V. Chaikovsky, M. Iu. Minakova & T. S. Markova

  2. Scientific Future Management Company, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev & P. G. Madonov

Authors
  1. A. M. Dygai
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  2. G. N. Zyuz’kov
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  3. V. V. Zhdanov
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  4. E. V. Udut
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  5. R. V. Gurto
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  6. L. A. Miroshnichenko
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  7. E. V. Simanina
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  8. T. Iu. Khrichkova
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  9. L. A. Stavrova
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  10. A. V. Chaikovsky
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  11. A. V. Artamonov
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  12. A. A. Bekarev
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  13. P. G. Madonov
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  14. M. Iu. Minakova
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  15. T. S. Markova
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Corresponding author

Correspondence to G. N. Zyuz’kov.

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Dygai, A.M., Zyuz’kov, G.N., Zhdanov, V.V. et al. Potentiation of Hemostimulating Effects of Erythropoietin with Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase. Bull Exp Biol Med 153, 684–688 (2012). https://doi.org/10.1007/s10517-012-1799-0

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  • DOI: https://doi.org/10.1007/s10517-012-1799-0

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