Opposite effects of amino acids on proliferation and differentiation of immune cells in organotypic culture of the spleen were demonstrated. It was found that methionine stimulates differentiation of CD5+ lymphocyte precursors into T-helpers, cytotoxic T lymphocytes, and B cells and induces proliferation of CD68+-macrophages. Glutamic acid and arginine induce proliferation of B cells, while histidine and leucine promote differentiation of precursors towards cytotoxic T cells. The opposite effects of amino acids on immune cells of the spleen are related to different hydrophobicity of their side chains determining the type of intermolecular interaction.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 102-105, April, 2012
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Kontcevaya, E.A., Linkova, N.S., Chalisova, N.I. et al. Effect of Amino Acids on Expression of Signal Molecules in Organotypic Culture of the Spleen. Bull Exp Biol Med 153, 573–576 (2012). https://doi.org/10.1007/s10517-012-1769-6
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DOI: https://doi.org/10.1007/s10517-012-1769-6