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Pharmacokinetics of Liposomal Gentamicin

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Bulletin of Experimental Biology and Medicine Aims and scope

We present data on pharmacokinetics of free and liposomal forms of gentamicin. Comparative study of two drug forms showed that immobilization of gentamicin in liposomes significantly increased most important pharmacokinetic parameters of the antibiotic (AUC, Сmax, MRTpo, Т1/2, Kel, Vzpo) and reduced Clpo and Kel.

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Authors and Affiliations

  1. Volgograd Antiplague Institute, Russian Agency for Health and Consumer Rights, Volgograd, Russia

    K. A. Rotov, S. N. Tikhonov, V. V. Alekseev & E. A. Snatenkov

Authors
  1. K. A. Rotov
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  2. S. N. Tikhonov
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  3. V. V. Alekseev
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  4. E. A. Snatenkov
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Corresponding author

Correspondence to K. A. Rotov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 4, pp. 464-466, April, 2012

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Rotov, K.A., Tikhonov, S.N., Alekseev, V.V. et al. Pharmacokinetics of Liposomal Gentamicin. Bull Exp Biol Med 153, 475–477 (2012). https://doi.org/10.1007/s10517-012-1744-2

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  • DOI: https://doi.org/10.1007/s10517-012-1744-2

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