Exocytosis inhibitor Exo 1 potentiates depression of acetylcholine-induced inward current in defensive behavior command neurons of edible snail, when acetylcholine is applied rhythmically to the soma in cellular correlate of habituation. A mathematical model presupposing different receptor localization in the cell and regularities of their translocations made it possible to analyze the dependence of acetylcholine-induced current depression on a number of intracellular processes. It was concluded that depression of choline-sensitive extrasynaptic zones on the membrane of defensive behavior command neurons in edible snail in cellular correlate of habituation is partially determined by attenuation of exocytosis of internalized cholinergic receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 4, pp. 410-413, April, 2012
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Makhnovskiy, D.A., Murzina, G.B. & Pivovarov, A.S. Cholinergic Receptor Exocytosis under Conditions of Depression of Acetylcholine-Induced Current in Edible Snail Neurons in Cellular Analogue of Habituation. Bull Exp Biol Med 153, 424–427 (2012). https://doi.org/10.1007/s10517-012-1731-7
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DOI: https://doi.org/10.1007/s10517-012-1731-7