Skip to main content
SpringerLink
Log in

Antitumor Effects of Monoclonal Antibodies to Connexin 43 Extracellular Fragment in Induced Low-Differentiated Glioma

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of intravenous administration of monoclonal antibodies to the second extracellular loop of connexin 43 (MAbE2Cx43) on the dynamics of glioma growth and survival of experimental animals. Morphometric analysis of magnetic resonance imaging data showed that weekly intravenous administration of MAbE2Cx43 in a dose of 5 mg/kg significantly reduced glioma volume starting from day 21 after tumor implantation. By day 29, the mean volume of glioma in the experimental group (therapy with specific antibodies) was 2-fold lower than in controls. Deceleration of glioma growth in rats receiving MAbE2Cx43 was accompanied by a significant prolongation of rat lifespan (according to Kaplan−Meier test) and even led to complete recovery without delayed relapses in 19.23% animals. The mechanism of tumor-suppressing effects of antibodies can be related to inhibition of specific functions of connexin 43 in glioma cells in the peritumoral zone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. P. Baklaushev, N. F. Grinenko, E. B. Tsitrin, et al., Br. J. Med. Medic. Res., 1, No. 2, 35-44 (2011).

    Google Scholar 

  2. V. P. Baklaushev, O. I. Gurina, G. M. Yusubalieva, et al., Bull. Exp. Biol. Med., 148, No. 4, 725-730 (2009).

    Article  PubMed  CAS  Google Scholar 

  3. V. P. Baklaushev, G. M. Yusubalieva, E. B. Tsitrin, et al., Drug Deliv., 18, No. 5, 331-337 (2011).

    Article  PubMed  CAS  Google Scholar 

  4. D. C. Bates, W. C. Sin, Q. Aftab, and C. C. Naus, Glia, 55, No. 15, 1554-1564 (2007).

    Article  PubMed  Google Scholar 

  5. J. D. Beatty, B. G. Beatty, W. G. Vlahos, J. Immunol. Methods, 100, Nos. 1-2, 173-179 (1987).

    Article  PubMed  CAS  Google Scholar 

  6. J. Behrens, P. Kameritsch, S. Wallner, et al., Eur. J. Cell. Biol., 89, No. 11, 828-838 (2010).

    Article  PubMed  CAS  Google Scholar 

  7. V. P. Chekhonin, V. P. Baklaushev, G. M. Yusubalieva, et al., Bull. Exp. Biol. Med., 143, No. 4, 501-509 (2007).

    Article  PubMed  CAS  Google Scholar 

  8. T. Demuth and M. E. Berens, J. Neurooncol., 70, No. 2, 217-228 (2004).

    Article  PubMed  Google Scholar 

  9. J. Dietrich, E. L. Diamond, and S. Kesari, Expert. Rev. Anticancer Ther., 10, No. 5, 171-175 (2010).

    Article  Google Scholar 

  10. F. B. Furnari, T. Fenton, R. M. Bachoo, et al., Genes Dev., 21, No. 21, 2683-2710 (2007).

    Article  PubMed  CAS  Google Scholar 

  11. F. Lefranc, M. Rynkowski, O. DeWitte, and R. Kiss, Adv. Tech. Stand. Neurosurg., 34, 3-35 (2009).

    Article  PubMed  CAS  Google Scholar 

  12. J. H. Lin, T. Takano , M. L. Cotrina, et al. J. Neurosci., 22, No. 11, 4302-4311 (2002).

    PubMed  CAS  Google Scholar 

  13. R. Oliveira, C. Christov, J. S. Guillamo, et al., BMC Cell Biology, 6, No. 1, 171-175 (2005).

    Article  Google Scholar 

  14. N. Prochnow and R. Dermietzel, Histochem. Cell. Biol., 130, No. 1, 71-77 (2008).

    Article  PubMed  CAS  Google Scholar 

  15. L. Soroceanu, T. J. Manning Jr., and H. Sontheimer, Glia, 33, No. 2, 107-117 (2001).

    Article  PubMed  CAS  Google Scholar 

  16. T. Suzuki, S. Izumoto, Y. Fujimoto, et al., J. Clin. Invest., 58, No. 2, 166-171 (2005).

    CAS  Google Scholar 

  17. G. H. Vince, M. Bendszus, T. Scweitzer, et al., Exp. Neurol., 190, No. 2, 478-485 (2004).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Fundamental and Applied Neurobiology, V. P. Serbskii State Research Center of Forensic and Social Psychiatry, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    G. M. Yusubalieva, V. P. Baklaushev, O. I. Gurina & V. P. Chekhonin

  2. Department of Medical Nanobiotechnologies, N. I. Pirogov National Research Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia

    G. M. Yusubalieva, V. P. Baklaushev & V. P. Chekhonin

  3. Center of Magnetic Resonance Tomography and Spectroscopy, M. V. Lomonosov Moscow State University, Moscow, Russia

    M. V. Gulyaev & Yu. A. Pirogov

Authors
  1. G. M. Yusubalieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. P. Baklaushev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. I. Gurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. V. Gulyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. A. Pirogov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. P. Chekhonin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. M. Yusubalieva.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 51-57, January, 2012

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yusubalieva, G.M., Baklaushev, V.P., Gurina, O.I. et al. Antitumor Effects of Monoclonal Antibodies to Connexin 43 Extracellular Fragment in Induced Low-Differentiated Glioma. Bull Exp Biol Med 153, 163–169 (2012). https://doi.org/10.1007/s10517-012-1667-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-012-1667-y

Key Words

Search

Navigation