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Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode

  • Experimental Methods for Clinical Practice
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied high-resolution 1H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the fi rst episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH2 protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH2 and CH3 protons of non-esterifi ed fatty acids were found in 1H nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

    T. A. Babushkina, T. P. Klimova & A. S. Peregudov

  2. Institute of Physicochemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia

    Yu. A. Gryzunov, N. V. Smolina & G. E. Dobretsov

  3. Institute of Psychiatry, Russian Ministry of Health Care and Social Development, Moscow, Russia

    M. G. Uzbekov

Authors
  1. T. A. Babushkina
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  2. T. P. Klimova
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  3. A. S. Peregudov
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  4. Yu. A. Gryzunov
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  5. N. V. Smolina
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  6. G. E. Dobretsov
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  7. M. G. Uzbekov
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Corresponding author

Correspondence to T. A. Babushkina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 694-697, December, 2011

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Babushkina, T.A., Klimova, T.P., Peregudov, A.S. et al. Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode. Bull Exp Biol Med 152, 748–751 (2012). https://doi.org/10.1007/s10517-012-1622-y

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  • DOI: https://doi.org/10.1007/s10517-012-1622-y

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