Effects of a sympatholytic drug on bone marrow stromal and hemopoietic precursors were studied on the model of cyclophosphamide-induced myelosuppression. Sympatholytic treatment increased the content of hemopoietic stem cells of different classes in the bone marrow. Selective stimulation of differentiation of polypotent precursors into granulocyte-macrophage precursors was noted. Acceleration of proliferation and maturation of granulocytic precursors was observed at later terms during regeneration of the hemopoietic tissue. The sympatholytic inhibited proliferation of stromal precursors and reduced feeder activity of fibroblasts for granulocyte precursors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 664–669, December, 2011
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Dygai, A.M., Khmelevskaya, E.S., Skurikhin, E.G. et al. Catecholamine regulation of stromal precursors and hemopoietic stem cells in cytostatic myelosuppression. Bull Exp Biol Med 152, 723–727 (2012). https://doi.org/10.1007/s10517-012-1616-9
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DOI: https://doi.org/10.1007/s10517-012-1616-9