Dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg) blocks stress-induced elevation of aldosterone concentration in rats subjected to repeated stress. Administration of DHEAS together with opioid receptor antagonist naltrexone in a dose of 0.1 mg/kg, i.e. the dose that selectively blocks μ-opioid receptors, abolished this blocking effect of DHEAS, which suggests that it is mediated by μ-opioid receptors. Under conditions of cold exposure, DHEAS exhibits the aldosterone-blocking effect even after single presentation of the stress factor. However, this effect is realized not via μ-opioid receptors, which attests to differences in the regulatory mechanisms depending on the nature of the external factor.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 635–637, December, 2011
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Obut, T.A., Saryg, S.K., Ovsukova, M.V. et al. Effect of dehydroepiandrosterone sulfate on aldosterone level during stress exposures: role of μ-opioid receptors. Bull Exp Biol Med 152, 696–698 (2012). https://doi.org/10.1007/s10517-012-1609-8
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DOI: https://doi.org/10.1007/s10517-012-1609-8