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Changes in Phospholipid Composition of the Spinal Cord in Rabbits with Allergic Encephalomyelitis as an Experimental Model of Multiple Sclerosis

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Bulletin of Experimental Biology and Medicine Aims and scope

Qualitative and quantitative composition of phospholipids in different compartments of the spinal cord was studied in normal rabbits and in experimental model of multiple sclerosis. The content of initial and final LPO products in compartments of the rabbit spinal cord was studied during different stages of the disease. The emergence of quantitative changes in the phospholipid composition depended on the form of experimental allergic encephalomyelitis and compartment of the spinal cord. The levels of conjugated dienes and MDA increased. The maximum levels of LPO products were recorded in the lumbar and sacral compartments of the spinal cord in severe experimental allergic encephalomyelitis.

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Authors and Affiliations

  1. N. P. Ogarev Mordovian State University, Saransk, Russia

    E. S. Revina, N. V. Gromova & T. E. Timoshina

Authors
  1. E. S. Revina
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  2. N. V. Gromova
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  3. T. E. Timoshina
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Correspondence to N. V. Gromova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No.8, pp. 184-187, August, 2011

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Revina, E.S., Gromova, N.V. & Timoshina, T.E. Changes in Phospholipid Composition of the Spinal Cord in Rabbits with Allergic Encephalomyelitis as an Experimental Model of Multiple Sclerosis. Bull Exp Biol Med 152, 224–227 (2011). https://doi.org/10.1007/s10517-011-1494-6

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  • DOI: https://doi.org/10.1007/s10517-011-1494-6

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