Experiments on spontaneously contracting strips from sinoatrial region of the hearts of 2-month-old albino mice showed that cesium (Cs+), a blocker of hyperpolarization-activated If current, in a concentration of 1 mM produced the greatest negative chronotropic effect on the duration of diastolic depolarization phase (75%), its rate (59%), and action potential duration (29%). The threshold concentration of Cs+ was approximately 0.15 mM. In a concentration of about 8.5 mM, spontaneous generation of action potentials stopped. The effect was reversible. Thus, blockade of If current by Cs+ reduced the rate of action potential generation in cells of mouse sinoatrial node by ~42% in comparison with controls.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 128-131, August 2011
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Gonotkov, M.A., Golovko, V.A. The Negative Chronotropic Effect of Cs+ Ions on Generation of Transmembrane Potentials in Mouse Sinoatrial Node Cells. Bull Exp Biol Med 152, 169–172 (2011). https://doi.org/10.1007/s10517-011-1479-5
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DOI: https://doi.org/10.1007/s10517-011-1479-5