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Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD+) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart

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In rat sinoatrial node, NAD+ (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases. In passed rabbit Purkinje fi bers, NAD+ (10 μM) reduced the duration of action potentials. Under conditions of spontaneous activity of Purkinje fi bers, NAD+ reduced the fi ring rate and the rate of slow diastolic depolarization. The effects of extracellular NAD+ on bioelectric activity of the pacemaker (sinoatrial node) and conduction system of the heart (Purkinje fi bers) are probably related to activation of P1 and P2 purinoceptors.

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References

  1. D. V. Abramochkin, S. V. Tapilina, and G. S. Sukhova, Bull. Exp. Biol. Med., 154, No. 3, 295-298 (2013).

    Article  CAS  PubMed  Google Scholar 

  2. V. S. Kuz’min, D. V. Abramochkin, G. S. Sukhova, and I. P. Ashmarin, Neyrokhimiya, 25, No. 1, 30-40 (2008).

    Google Scholar 

  3. V. S. Kuz’min, D. V. Abramochkin, G. S. Sukhova, and L. V. Rozenshtraukh, Kardiologiya, 48, No. 11, 53-60 (2008).

    PubMed  Google Scholar 

  4. K. B. Pustovit, V. S. Kuz’min, and G. S. Sukhova, Ross. Fiziol. Zh., 100, No. 4, 445-457 (2014).

    CAS  Google Scholar 

  5. F. Berger, M. H. Ramirez-Hernández, and M. Ziegler, Trends Biochem. Sci., 29, No. 3, 111-118 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. G. Burnstock, Physiol. Rev., 87, No. 2, 659-797 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. W. G. Ding, F. Toyoda, and H. Matsuura, J. Biol. Chem., 279, No. 49, 50 726-50 734 (2004).

  8. H. Matsuura and T. Ehara, J. Physiol., 503, Pt. 1, 45-54 (1997).

  9. H. Matsuura, Y. Tsuruhara, M. Sakaguchi, and T. Ehara, J. Physiol., 490, Pt. 3, 647-658 (1996).

  10. H. Musa, J. O. Tellez, N. J. Chandler, et al., Arch. Pharmacol., 379, No. 6, 541-549 (2009).

    Article  CAS  Google Scholar 

  11. L. M. Ren, J. X. Li, C. S. Shi, and D. Zhao, Acta Pharmacol. Sin., 24, No. 9, 943-947 (2003).

    CAS  PubMed  Google Scholar 

  12. L. M. Smyth, I. A. Yamboliev, and V. N. Mutafova-Yambolieva, Neuropharmacology, 56, No. 2, 368-378 (2009).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. H. Toda, W. G. Ding, Y. Yasuda, et al., Br. J. Pharmacol.,150, No. 8, 1011-1021 (2007).

  14. I. A. Yamboliev, L. M. Smyth, L. Durnin, et al., Eur. J. Neurosci., 30, No. 5, 756-768 (2009).

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia

    K. B. Pustovit, V. S. Kuz’min & G. S. Sukhova

  2. Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    K. B. Pustovit & V. S. Kuz’min

Authors
  1. K. B. Pustovit
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  2. V. S. Kuz’min
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  3. G. S. Sukhova
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Correspondence to K. B. Pustovit.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 2, pp. 144-147, February, 2015

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Pustovit, K.B., Kuz’min, V.S. & Sukhova, G.S. Effect of Exogenous Extracellular Nicotinamide Adenine Dinucleotide (NAD+) on Bioelectric Activity of the Pacemaker and Conduction System of the Heart. Bull Exp Biol Med 159, 188–191 (2015). https://doi.org/10.1007/s10517-015-2919-4

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  • DOI: https://doi.org/10.1007/s10517-015-2919-4

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